解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Epstein-Barr virus (EBV) is a human herpesvirus hiding in a latent form in memory B cells in the majority of the world population. Although, primary EBV infection is asymptomatic or causes a self-limiting disease, infectious mononucleosis, the virus is associated with a wide variety of neoplasms developing in immunosu...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930802024772
更新日期:2008-05-01 00:00:00
abstract::Diabetes mellitus is a disorder characterized by hyperglycemia in both the fasting and post-prandial states. The two most common forms of diabetes mellitus, type 1 and type 2 (previously called juvenile-onset and adult-onset, respectively), comprise the vast majority of cases. Type 1 diabetes (T1DM) has been shown to ...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701619169
更新日期:2008-02-01 00:00:00
abstract::The immunomodulatory effects of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been elucidated at a cellular level and implicated in the pathogenesis of several complex diseases. Defects within the regulatory T cell compartment are one of the characteristics of primary biliary cirrhosis (PBC...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701619730
更新日期:2008-02-01 00:00:00
abstract::The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencie...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701510673
更新日期:2007-12-01 00:00:00
abstract::Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes utilizing a novel recombinant PR3 (rPR3) produced to accommodate manipulations of the N-terminal domain. The rPR3 molecule contains an N-terminus six ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701680104
更新日期:2007-11-01 00:00:00
abstract::The Foxo subfamily of forkhead (Fox) transcription factors are mammalian homologues of the Caenorhabditis elegans DAF-16 longevity gene, and play key roles in cellular and organism survival, death, proliferation and metabolism. A growing body of evidence indicates that Foxo proteins furthermore play critical roles in ...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701464913
更新日期:2007-09-01 00:00:00
abstract::The objective of this study was to identify new autoantibodies that could be useful for the diagnosis of rheumatoid arthritis (RA) using immunoblotting on synovial membrane proteins which represent the best source of candidate RA autoantigens. A new target protein with a molecular weight of 26 kDa was found to be reco...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701417473
更新日期:2007-07-01 00:00:00
abstract::DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701358826
更新日期:2007-06-01 00:00:00
abstract::Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701356846
更新日期:2007-06-01 00:00:00
abstract::Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701262986
更新日期:2007-05-01 00:00:00
abstract::The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins including ionized Ca(2+)-binding adaptor 1, microglia response factor-1, and daintain are identical with AIF-1. The expre...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930601083946
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:Autoimmune sensorineural hearing loss (ASNHL) is a relatively rare disorder which can lead to total deafness. At present, no specific laboratory test with adequate sensitivity and specificity is available to confirm the clinical suspicion of ASNHL. The aim of this study was to identify if evaluation of anti-...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930601119377
更新日期:2007-02-01 00:00:00
abstract::Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930601062437
更新日期:2006-12-01 00:00:00
abstract::Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600971836
更新日期:2006-11-01 00:00:00
abstract::A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600847598
更新日期:2006-09-01 00:00:00
abstract::The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930600739647
更新日期:2006-08-01 00:00:00
abstract::Type 1 diabetes (T1D) is characterized by selective autoimmune destruction of the insulin producing beta-cells in the islets of Langerhans. When the beta-cells are destroyed exogenous administration of insulin is necessary for maintenance of glucose homeostasis. Allogeneic islet transplantation has been used as a mean...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600648269
更新日期:2006-06-01 00:00:00
abstract::This review focuses on recent advances and new hypothesis in the understanding of the T and dendritic cells contribution to the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). The new data show that non-specific amplification of muscle inflammation by T...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930600622173
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To assess muscle strength in patients with idiopathic inflammatory myopathies (IIM) using neuromuscular scales and isokinetic testing. METHODS:Muscle function was evaluated in 27 IIM patients being followed at the Rheumatology Unit of the University of Pisa using: (i) a modified version of the grading system...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600623817
更新日期:2006-05-01 00:00:00
abstract::Under-nutrition impairs immune responses, but far less is known about the impact of over-nutrition, such as obesity, on the response to vaccines. We measured the effect of childhood overweight status on inflammatory mediators, circulating immunoglobulins and tetanus antibodies in fifteen overweight children (BMI > 85 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600597326
更新日期:2006-03-01 00:00:00
abstract::Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strept...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930500484674
更新日期:2006-02-01 00:00:00
abstract::Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic beta cell destruction involving auto-reactive T-cells, pro-inflammatory cytokines, reactive oxygen species (ROS) and loss of insulin. Monozygotic twin studies show a 20-60% concordance with T1D indicating there may be an environmental component...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500407238
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Thalidomide is used in cutaneous lupus erythematosus (CLE) refractory to conventional therapies. Peripheral neuropathy (PN) is the most severe side effect, but the incidence of PN and its relation to thalidomide dose are still unclear. OBJECTIVE:To prospectively evaluate the efficacy as well as the occurren...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500285790
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:Autoantibodies to tumor-associated antigens including survivin have been detected in sera from patients with hepatocellular carcinoma (HCC). However, little is known about autoantibody responses to tumor-associated antigens in patients with chronic hepatitis, which strongly predisposes to development of HCC....
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500289958
更新日期:2005-09-01 00:00:00
abstract::Programmed cell death 1 (PD-1) was isolated in 1992 by subtractive-hybridization technique, as a molecule whose expression is enhanced by apoptotic stimuli. Since then we have been analyzing the function of PD-1 in the regulation of immune responses. Generation of PD-1 deficient mice, pathophysiological analyses of au...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930500124072
更新日期:2005-08-01 00:00:00
abstract::Autoimmune diabetes is an organ specific and multifactorial disorder with a classical onset as insulin dependent diabetes mellitus (IDDM) and with another form of onset as latent autoimmune diabetes in adults (LADA), which has a slower onset and a later progress to insulin dependency as a result of the beta cells dest...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500158203
更新日期:2005-06-01 00:00:00
abstract::The presence of autoimmune rheumatic diseases in several members of the same family, the concurrence of autoimmune rheumatic with non-rheumatic diseases in relatives of patients, the presence of autoantibodies in sera from healthy relatives of autoimmune-disease patients, the development of two or more autoimmune rheu...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500050145
更新日期:2005-05-01 00:00:00
abstract::Systemic sclerosis (SSc) is characterized by extensive fibrosis, vasculopathy and activation of the immune system. Fibrosis can be caused by profibrotic cytokines, such as transforming growth factor-beta (TGFbeta), interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective tissue growth factor. Vascul...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/16066350500095415
更新日期:2005-03-01 00:00:00
abstract::Rheumatoid factors (RF), which are antibodies (Ab) with specificity directed against gamma (?) globulins, are the commonest auto-Ab ever described in man. Some of them are referred to as agglutinating RF, others designated non-agglutinating RF. Not only do these characterize rheumatoid arthritis (RA), but they are als...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930400022574
更新日期:2005-02-01 00:00:00
abstract::Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis. Using indirect immunofluorescence on ethanol-fixed neutrophils, two major fluoroscopic patterns can be recognised: a diffuse cytoplasmic staining (C-ANCA), and a perinuclear/nuclear staining (P-ANC...
journal_title:Autoimmunity
pub_type: 历史文章,杂志文章,评审
doi:10.1080/08916930400022673
更新日期:2005-02-01 00:00:00
abstract::A robust and precise enzyme linked immunosorbent assay (ELISA) with proven sensitivity and specificity has been employed to detect human antibodies (allogenic/autogenic) to human acetylcholinesterase (AChE). The sensitivity of the method has been established using mouse monoclonal antibodies (0.8 ng/ml) and uniquely, ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930400021360
更新日期:2004-12-01 00:00:00
abstract::NZW "x" BXSB F1 mice develop SLE that is associated with an anti-phospholipid syndrome characterized by anti-cardiolipin antibodies, thrombocytopenia and small coronary artery thrombosis. This syndrome is immune mediated and, dependent, on CD4+T cells. To determine whether disease in these mice can be treated with blo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930400008524
更新日期:2004-09-01 00:00:00
abstract::Guillain-Barre syndrome (GBS) is an autoimmune disorder of the peripheral nervous system. However, GBS patients frequently display a psychosyndrome, indicating an accompanying involvement of the central nervous system (CNS), although the cause is not understood. Hepatic encephalopathy is possibly the best characterize...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930412331279840
更新日期:2004-09-01 00:00:00
abstract::Numerous groups have now validated high-throughput approaches to autoantibody profiling in a variety of systems. Recently, we have used autoantigen microarray technology to identify distinct autoantibody profiles in H-2 congenic MRL/lpr mice (Sekine et al., manuscript in preparation), and we are expanding this platfor...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930410001710686
更新日期:2004-06-01 00:00:00
abstract::Human Toll-like receptors (TLRs) are crucial for the recognition of invading pathogens and for the activation of both innate and adaptive immunity. Upon stimulation, TLRs recruit various protein kinases via several adaptor molecules, such as MyD88, leading to the activation of NFkB. The identification of TLR signaling...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930410001704944
更新日期:2004-05-01 00:00:00
abstract::Numerous studies have shown that autoantigens may be clustered in the blebs of apoptotic cells. However, it is not yet clear in what circumstances apoptotic cells could be immunogenic rather than tolerogenic when interacting with macrophages, dendritic cells, and B cells. In order to further study this question we com...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930410001666622
更新日期:2004-03-01 00:00:00
abstract::A flow cytometry-based phagocytosis assay was developed and utilized to measure the LE cell phenomenon at the single cell level in vitro. Since the lupus erythematosus (LE) cell phenomenon is a special form of necro-phagocytosis in the presence of anti-dsDNA antibodies, dead substrate cells or chicken erythrocytes nuc...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930310001630325
更新日期:2004-02-01 00:00:00
abstract::Epitopes for > 95% stimulating thyrotropin receptor autoantibodies (TSHRAbs) causally implicated in Graves' disease (Basedow's disease or primary hyperthyroidism) have been identified on on the N-terminal portion of the TSHR extracellular domain, residues 8-165. If the stimulating TSHRAb activity is solely dependent o...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930310001604199
更新日期:2003-09-01 00:00:00
abstract::Decades of research have provided strong evidence for a reciprocal relationship between the immune system and hormones of the hypothalamus-pituitary-thyroid (HPT) axis. Thyroid stimulating hormone (TSH), in particular, has been shown to have a variety of immune-regulating cytokine-like activities that can influence th...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930310001603019
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:Henoch-Schonlein purpura (HSP) is a systemic vasculitis characterized by IgA-containing deposits in the skin, joints, gastrointestinal mucosa and glomeruli. HSP is much rarer in adults than in children. Among a number of other pathogenic factors, Helicobacter pylori (Hp) has recently been implicated in the ga...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930232000114535
更新日期:2003-08-01 00:00:00